Skip to languages: fr en es de it pt orphanet index there is no disease so rare that it does not deserve attention homepage about orphanet help contact us main menu : rare diseases orphan drugs expert centres diagnostic tests research and trials patient organisations professionals and institutions other information submenu : search search by sign classifications genes encyclopaedia for patients encyclopaedia for professionals emergency guidelines navigation tree : homepage rare diseases search print simple search simple search enter keywords * (*) mandatory field disease name gene name or symbol omim icd-10 orpha number  simple search other search option(s) alphabetical list niemann-pick disease type c orpha number orpha646 synonym(s) - prevalence 1-9 / 1 000 000 inheritance autosomal recessive age of onset variable icd-10 e75. Reliable viagra online forum generic viagra online 2 omim - umls c0220756 mesh d052556 meddra - snomed ct 66751000 summary niemann-pick disease type c (completely distinct from types a and b) is a complex lysosomal lipidosis resulting in hepatosplenomegaly and progressive neurological involvement. cheap generic viagra cheap generic viagra no prescription The estimated prevalence is approximately 1/130 000 births. buy viagra uk pharmacy buy viagra uk pharmacy The clinical picture is extremely heterogeneous, the age of onset varying between the perinatal period and the age of 50 years or more. delayed ejaculation viagra side effects Viagra india mt tadalafil Cases of hydrops foetalis have been described (rare). vision problems with viagra buy viagra uk pharmacy In 40% of cases, the neonatal period is marked by hepatosplenomegaly associated with prolonged cholestatic jaundice that usually regresses spontaneously but sometimes progresses to rapidly fatal liver failure. viagra 72 hours buy cheap viagra The finding of hepato- and/or splenomegaly in the child is a very frequent sign, which can remain isolated for a very variable period, before the beginning of neurological symptoms. buy generic viagra cheap viagra online The age of onset of these symptoms and their evolution will determine the degree of severity of the disease. discounted generic viagra In the severe infantile form (20% of cases), the onset of neurological involvement occurs before age 2 with delay in motor milestones and hypotonia, followed by pyramidal signs. viagra without a doctor prescription In the other forms, occurring much more frequently, typical neurological signs include cerebellar ataxia an. cheap viagra pills online What happens if you take viagra and viagra at the same time